Transfer RX

Home / Prescribing pharmacist / Mirena, Kyleena, and Jaydess

Reproductive health · 9 min read

Jaydess vs Kyleena vs Mirena: which hormonal IUD is right for you?

Side-by-side comparison · Mirena vs. Kyleena vs. Jaydess

All three are levonorgestrel IUDs from the same manufacturer, on the same T-shaped frame. They differ in frame size, hormone dose, approved duration, and effect on periods. Knowing the differences makes choosing one simpler.

Side by side

  • Mirena. Up to 8 years. ~20 mcg/day levonorgestrel. Largest frame. ~20% of users stop menstruating within year 1. Approved for both contraception and heavy menstrual bleeding.
  • Kyleena. Up to 5 years. ~17.5 mcg/day. Smaller frame. ~12% stop menstruating within year 1. Contraception only.
  • Jaydess. Up to 3 years. ~14 mcg/day. Smallest frame. ~6% stop menstruating within year 1. Contraception only.

Mirena: maximum duration, period control

Mirena is the largest, highest-dose option. About 20% of users stop menstruating entirely within the first year. Most others see substantially reduced flow. Mirena holds Health Canada approval as a standalone treatment for menorrhagia (heavy bleeding), independent of contraceptive use, which makes it the right call for many patients with heavy or painful periods. The larger frame may cause more insertion discomfort for nulliparous individuals (those who haven't been pregnant).

Kyleena: the middle ground

Kyleena's smaller frame delivers ~17.5 mcg/day initially, over five years. About 12% of users stop menstruating within year 1, with the rest typically seeing lighter periods. Clinical data suggests improved insertion tolerability for nulliparous individuals.

Jaydess: lowest hormone, shortest commitment

Jaydess offers the lowest systemic exposure with the lowest dose and a three-year approved lifespan. Only about 6% of users achieve complete period cessation. The trade-offs are more frequent replacement and higher cumulative cost over time, but for patients who want minimal hormones it's the cleanest option.

Copper IUDs: the hormone-free option

Three copper options are available in Canada: Mona Lisa, Liberté, and Flexi-T. They release copper ions that are toxic to sperm. Lifespan: 3 to 10 years depending on model. Copper IUDs typically make periods heavier, longer, and more crampy, especially during the first 3 to 6 months. They're also over 99% effective as emergency contraception within 5 days.

How to decide

  • Maximum duration: Mirena
  • Lightest periods or treatment for heavy periods: Mirena
  • Smaller frame, easier insertion (especially nulliparous): Kyleena or Jaydess
  • Minimum hormone exposure: Jaydess
  • Hormone-free, willing to accept heavier periods: copper IUD
  • Need EC and long-term contraception in one step: copper IUD

Insertion, removal, fertility return

Removal is brief and outpatient, doable any time during the device's approved lifespan. Fertility returns immediately, ovulation can resume within the first cycle after removal. We coordinate insertion at Meadowlark Place, typically within one week of prescription.

Insurance and cost

Alberta Blue Cross covers all options under most plans. Out-of-pocket costs typically range from $100 to $300 depending on device. We bill direct to most drug benefit plans.

What our pharmacist can do

Prescribe all three hormonal IUDs. Coordinate your insertion appointment at Meadowlark Place. Walk you through the trade-offs in a private consultation room before you commit. Answer questions about side effects, expulsion risk, perforation rates, and what to expect during the first three months. If an IUD is not the right fit for you, your Acme pharmacist can also prescribe birth control like the pill, the patch or the ring, with no doctor visit needed.

Walk in or call

(780) 443-0202. Unit 103, 15508 87 Ave NW, Meadowlark Place, Edmonton.

Common questions

IUD FAQ.

What is the difference between Mirena, Kyleena, and Jaydess?

All three are levonorgestrel IUDs from the same manufacturer. Mirena lasts up to 8 years with the highest dose and largest frame. Kyleena lasts up to 5 years with a smaller frame. Jaydess lasts up to 3 years with the lowest hormone dose and smallest frame. They differ in how much they reduce or stop periods.

Can a pharmacist prescribe an IUD in Edmonton?

Yes. The pharmacist at Acme Drug Mart in Edmonton can prescribe all three hormonal IUDs and coordinate your insertion appointment at Meadowlark Place, typically within one week of your prescription.

How much does an IUD cost in Alberta?

Out-of-pocket costs typically range from $100 to $300 depending on the device. Alberta Blue Cross covers all IUD options under most plans. Acme Drug Mart bills directly to most drug benefit plans.

Which IUD is best for heavy periods?

Mirena is the best option for heavy periods. It holds Health Canada approval as a standalone treatment for menorrhagia (heavy menstrual bleeding). About 20% of Mirena users stop menstruating entirely within the first year, and most others see substantially reduced flow.

Does fertility return after IUD removal?

Yes. Fertility returns immediately after IUD removal. Ovulation can resume within the first menstrual cycle after the device is taken out. Removal is a brief outpatient procedure.

Which IUD has the lowest hormones?

Jaydess offers the lowest systemic hormone exposure at approximately 14 mcg per day of levonorgestrel. It lasts 3 years and only about 6% of users stop menstruating. For patients who want a completely hormone-free option, a copper IUD is available.

Prescription plus insertion

Walk in for the consultation.

Pharmacist can prescribe all three hormonal IUDs and book your insertion at Meadowlark Place, typically within a week.